Helicobacter Pylori Infection: Management & Treatment Menu

How to Manage Helicobacter Pylori Infection

Once Helicobacter pylori infection has been established, treatment is indicated. The treatment depends on macrolide (clarithromycin) and penicillin antibiotics, and for patients with macrolide resistance or with penicillin allergies, alternative treatments are used. Treatment is up to 14 days.

Traditional clarithromycin-based triple therapy (14 days):

  • Protein pump inhibitor
  • Amoxicillin. In those with a penicillin allergy, metronidazole (Flagyl) can be substituted
  • Clarithromycin

Alternative therapy for macrolide (clarithromycin) resistance.

Bismuth quadruple therapy (14 days):

  • Bismuth
  • Subsalicylate
  • Metronidazole
  • Tetracycline

Levofloxacin triple therapy (10-14 days):

  • Levofloxacin
  • Amoxicillin
  • Protein pump inhibitor

Levofloxacin quadruple therapy (7-10 days):

  • Omeprazole
  • Nitazoxanide
  • Doxycycline

Each of these categories of therapy have a “sequential version” that entails timing the agents along a skewed timeline.


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This information is provided by Vascular Health Clinics and is not intended to replace the medical advice of your doctor or healthcare provider. Please consult your healthcare provider for advice about a specific medical condition.

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