Treatment of Thrombosis with Antiplatelet Therapy
An overreaction of the clotting process with premature, unprovoked, or exaggerated platelet initiation can be managed using medications that interfere with this, called antiplatelet agents:
- Aspirin: in doses of 50-100 mg/day
- Non-aspirin NSAIDs: non-steroidal anti-inflammatory drugs. Complications can include upper gastrointestinal bleeding and gastritis
- Platelet receptor site antagonists: interfere with platelet activation ,P2Y12 receptor blockers (e.g., clopidogrel, prasugrel, ticagrelor), glycoprotein IIb/IIIa inhibitors (e.g., abciximab, tirofaban, eptifibatide).
- Nitrates: Reduce platelet reactivity, adhesion, and aggregation.
- Calcium channel blockers: Reduce platelet aggregation and adhesion.
- Heparin: reduces platelet adhesion.
- Warfarin: not a true antiplatelet medication but a vitamin K antagonist, it is used for longterm anticoagulation in those who prefer pills or who have recurrent embolic events.
Oral antiplatelet preparations include aspirin, NSAIDs, calcium channel blockers, warfarin, rivaroxaban, apixaban, edoxaban, and dabigatran.
Non-Medical Antiplatelet Treatment
If patients fail to achieve ideal anticoagulation or who have recurrent thrombus or thromboembolic events, a filter can be placed in the vena cava to catch venous migratory clots before they reach the right-sided heart circulation to the lungs.