Platelet Function Assays: Prevention Menu

Prevention of Platelet Dysfunction

Prevention of platelet dysfunction relies on screening methods, such as blood work and platelet function testing in those at risk, such as patients with a strong history of bleeding diathesis (disorders), venous thrombosis, hemophilia, stroke, and inappropriate blood loss after minor trauma. A family history positive for platelet dysfunction is a major risk that calls for preventative measures. Identification of those as risk is the best strategy for preventing stroke, hemorrhage, gastrointestinal bleeding, surgery-associated blood loss, and spontaneous bleeding.

Prevention of Clotting

  • Those with an increased tendency toward clotting (i.e., previous thrombosis, strong family history, previous stroke, venous stasis, or atherosclerosis): May benefit from anti-platelet therapy, using aspirin, NSAIDs, heparin, warfarin, or other agents.

Prevention of Bleeding

  • Those with an increased tendency toward, or history of, uncontrolled bleeding: Can be treated preventatively with desmopressin, estrogens, or in critical thrombocytopenia where hemorrhagic stroke is likely, platelet transfusion. Stroke prevention is a major incentive for such preventative therapy.
  • Prevention of the causes of platelet dysfunction: Can also prevent the dysfunction, such as prevention of liver disease (alcohol rehabilitation and avoiding high-risk sexual behavior that increases the risk of acquiring hepatitis B and C) and aggressive approaches to kidney disease.
  • Using therapeutic agents is prudent when there is a planned surgery involving cardiopulmonary bypass.
  • Strict glycemic control in diabetics: With a targeted hemoglobin A1c goal of >7%, can reduce the risk of bleeding diathesis in diabetics.

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This information is provided by Vascular Health Clinics and is not intended to replace the medical advice of your doctor or healthcare provider. Please consult your healthcare provider for advice about a specific medical condition.

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